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Products Details
Product Description
– FGFR4-IN-11 (Compound 30) is a potent, selective, covalent FGFR4 inhibitor with an IC50 of 2.1 nM. FGFR4-IN-11 significantly inhibits the FGF19/FGFR4 signaling pathway and shows antitumor activity[1].
Web ID
– HY-147515
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C29H29N5O5
References
– [1]Zhong Z, et al. Discovery of Novel 7-Azaindole Derivatives as Selective Covalent Fibroblast Growth Factor Receptor 4 Inhibitors for the Treatment of Hepatocellular Carcinoma. J Med Chem. 2022 May 26;65(10):7278-7295.
CAS Number
– 2396664-85-8
Molecular Weight
– 527.57
SMILES
– COC1=CC(C(C2=CNC3=NC(NC4=C(C=C(C=C4)N5CCOCC5)NC(C=C)=O)=CC=C32)=O)=CC(OC)=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Isoform
– FGFR4
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
