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Products Details
Product Description
– FGFR4-IN-10 (compound 5a) is a potent and selective FGFR4 inhibitor with an IC50 value of 70.7 nM. FGFR4-IN-10 shows no inhibition against other FGFR family members, i.e. FGFR1, FGFR2 and FGFR3[1].
Web ID
– HY-146541
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C20H19F3N6O3
References
– [1]Zhen Zhang, et al. Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design. Bioorg Med Chem. 2021 Nov 15;50:116457.
CAS Number
– 2857862-25-8
Molecular Weight
– 448.40
SMILES
– COCCNC1=C(C=NC(NC(N2CCCC3=CC=C(N=C32)C(C(F)(F)F)=O)=O)=C1)C#N
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Isoform
– FGFR4
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
