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Products Details
Product Description
– FGFR1 inhibitor 7 (compound 5) is an inhibitor of FGFR1 Tyrosine Kinase with IC50 value of 0.33 nM. FGFR1 inhibitor 7 shows broad-spectrum cytotoxicity agasinst human cancer cell lines, and inhibits MOLT3 cells with IC50 of 2.1 μM[1].
Web ID
– HY-149486
Shipping
– Room temperature
Molecular Formula
– C25H16ClNO4
References
– [1]Leechaisit R, et al. Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling[J]. ACS Omega, 2023. .
Molecular Weight
– 429.85
SMILES
– O=C1C(Cl)=C(NC2=CC=CC(C(/C=C/C3=CC=C(O)C=C3)=O)=C2)C(C4=C1C=CC=C4)=O
Clinical Information
– No Development Reported
Research Area
– cancer
Solubility
– 10 mM in DMSO
Target
– FGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
