Download Files:
Products Details
Product Description
– FAK-IN-16 (compound OXA-11) is an orally active, selective focal adhesion kinase (FAK) inhibitor with an IC50 of 1.2 pM. FAK-IN-16 inhibits FAK phosphorylation at pFAK[Y397] and pFAK[Y861]. FAK-IN-16 slows tumor growth and reduces tumor vascularity, invasion. FAK-IN-16 potentiates effects of Cisplatin (HY-17394) on tumor cell proliferation and apoptosis in vitro and anti-tumor actions in mice[1].
Web ID
– HY-117836
Shipping
– Room temperature
Molecular Formula
– C37H49F3N7O5P
References
– [1]Ingrid Moen, et al. Anti-metastatic action of FAK inhibitor OXA-11 in combination with VEGFR-2 signaling blockade in pancreatic neuroendocrine tumors. Clin Exp Metastasis. 2015 Dec;32(8):799-817.
CAS Number
– 1257994-15-2
Molecular Weight
– 759.80
SMILES
– COC1=CC(CP(OCC)(OCC)=O)=CC=C1NC2=NC=C(C(F)(F)F)C(NC3=CC=C([C@H]4CC[C@H](N5CCN(C)CC5)CC4)C(CN6C)=C3C6=O)=N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– FAK
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
