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Products Details
Product Description
– EP3 antagonist 4 (Compound 28) is an EP3 antagonist, with a Ki value of 2 nM for hEP. EP3 antagonist 4 shows low in vivo clearance, high oral AUC, and good bioavailability in the rat full PK studies. EP3 antagonist 4 can be used for research of beta cell dysfunction in diabetes[1].
Web ID
– HY-153256
Shipping
– Room temperature
Applications
– Metabolism-protein/nucleotide metabolism
Molecular Formula
– C22H20Cl3FN4O3S2
References
– [1]Zhu B, et al. Discovery and Optimization of 7-Alkylidenyltetrahydroindazole-Based Acylsulfonamide EP3 Antagonists. ACS Med Chem Lett. 2021 Dec 7;13(1):111-117.
CAS Number
– 2408297-80-1
Molecular Weight
– 577.91
SMILES
– O=S(NC(NC/C(F)=C1CCCC(C=N2)=C1N2CC3=C(C=C(C=C3)Cl)Cl)=O)(C4=CC(C)=C(S4)Cl)=O
Clinical Information
– No Development Reported
Research Area
– Metabolic Disease
Solubility
– 10 mM in DMSO
Target
– Prostaglandin Receptor
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
