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Ensartinib (dihydrochloride)
$180 – $1,500
Products Details
Product Description
– Ensartinib dihydrochloride (X-396 dihydrochloride) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively.
Web ID
– HY-103714A
Storage Temperature
– 4°C (Powder, sealed storage, away from moisture)
Shipping
– Room Temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C26H29Cl4FN6O3
Citations
– Drug Des Dev Ther. 2020 Nov 30;14:5259-5273.|Cancers. 2020 Mar 28;12(4):813.
References
– [1]Lovly CM, et al. Insights into ALK-driven cancers revealed through development of novel ALK tyrosine kinaseinhibitors. Cancer Res. 2011 Jul 15;71(14):4920-31.
CAS Number
– 2137030-98-7
Molecular Weight
– 634.36
Compound Purity
– 99.53
SMILES
– O=C(C1=NN=C(N)C(O[C@@H](C2=C(Cl)C=CC(F)=C2Cl)C)=C1)NC3=CC=C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)C=C3.Cl.Cl
Clinical Information
– Launched
Research Area
– Cancer
Solubility
– DMSO : 35.71 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic)
Target
– Anaplastic lymphoma kinase (ALK);c-Met/HGFR
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
