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Daphnetin
$35 – $385
Products Details
Product Description
– Daphnetin (7,8-dihydroxycoumarin), one coumarin derivative can be found in plants of the Genus Daphne, is a potent, oral active protein kinase inhibitor, with IC50s of 7.67 μM, 9.33 μM and 25.01 μM for EGFR, PKA and PKC in vitro, respectively. Daphnetin triggers ROS-induced cell apoptosis and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway. Daphnetin has anti-inflammation activitity and inhibits TNF-α, IL-1ß, ROS, and MDA production. Daphnetin has schizontocidal activity against malaria parasites. Daphnetin can be used for rheumatoid arthritis , cancer and anti-malarian research[1][2][3][4].
Web ID
– HY-N0281
Storage Temperature
– -20°C, 3 years; 4°C, 2 years (Powder)
Shipping
– Room Temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C9H6O4
References
– [1]Fan X, et, al. Daphnetin triggers ROS-induced cell death and induces cytoprotective autophagy by modulating the AMPK/Akt/mTOR pathway in ovarian cancer. Phytomedicine. 2021 Feb;82:153465.|[2]Zhang L, et, al. Daphnetin protects against cisplatin-induced nephrotoxicity by inhibiting inflammatory and oxidative response. Int Immunopharmacol. 2018 Dec;65:402-407.|[3]Wang QM, et, al. The schizontocidal activity of daphnetin against malaria parasites in vitro and in vivo. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2000;18(4):204-6.|[4]Yang EB, Zhao YN, Zhang K, Mack P. Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor. Biochem Biophys Res Commun. 1999 Jul 14;260(3):682-5.
CAS Number
– 486-35-1
Molecular Weight
– 178.14
Compound Purity
– 99.86
SMILES
– O=C1C=CC2=CC=C(O)C(O)=C2O1
Clinical Information
– Launched
Research Area
– Inflammation/Immunology; Cancer
Solubility
– DMSO : 50 mg/mL (ultrasonic)|H2O : 1 mg/mL (ultrasonic)
Target
– Akt;AMPK;Apoptosis;Autophagy;Bcl-2 Family;Caspase;EGFR;mTOR;Parasite;PARP;PKA;PKC;Reactive Oxygen Species
Isoform
– EGFR/ErbB1/HER1;PKA;PKC;Plasmodium
Pathway
– Anti-infection;Apoptosis;Autophagy;Cell Cycle/DNA Damage;Epigenetics;Immunology/Inflammation;JAK/STAT Signaling;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt;TGF-beta/Smad
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
