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Products Details
Product Description
– CLK1/4-IN-1 (compound 31) is a potent and selective Clk1 and Clk4 inhibitor with an IC50 value of 9.7 nM and 6.6 nM, respectively. CLK1/4-IN-1 has growth inhibitory activities against T24 cancer cells with GI50 of 1.1 μM. CLK1/4-IN-1 can be used for researching anticancer[1].
Web ID
– HY-146335
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C18H14ClNO4S
References
– [1]El-Gamil DS, et al. Development of novel conformationally restricted selective Clk1/4 inhibitors through creating an intramolecular hydrogen bond involving an imide linker [published online ahead of print, 2022 Apr 26]. Eur J Med Chem. 2022;238:114411.
Molecular Weight
– 375.83
SMILES
– O=C(NC(C1=C(C=CC(Cl)=C1)OC)=O)C2=CC3=CC(OC)=CC=C3S2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– CDK
Isoform
– CLK
Pathway
– Cell Cycle/DNA Damage
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
