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CAY10471
$156
Only 1000 item(s) left in stock.
Products Details
Product Description
– CAY10471 (TM30089) is a potent, selective, and orally active prostaglandin D2 receptor CRTH2 antagonist. CAY10471 attenuates the progression of tubulointerstitial fibrosis and chronic contact hypersensitivity (CHS) in animal model[1][2][3].
Web ID
– HY-13706A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C21H21FN2O4S
References
– [1]Hatanaka M, et al. 15d-prostaglandin J2 enhancement of nerve growth factor-induced neurite outgrowth is blocked by the chemoattractant receptor- homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist CAY10471 in PC12 cells. J Pharmacol Sci. 2010;113(1):89-93. Epub 2010 Apr 16.|[2]Matsushima Y, et al. Distinct roles of prostaglandin D2 receptors in chronic skin inflammation.Mol Immunol. 2011 Oct;49(1-2):304-10.|[3]Ito H, et al. PGD2-CRTH2 pathway promotes tubulointerstitial fibrosis.J Am Soc Nephrol. 2012 Nov;23(11):1797-809.
CAS Number
– 627865-18-3
Molecular Weight
– 416.47
SMILES
– O=C(CN1C2=C(CC(CC2)N(C)S(=O)(C3=CC=C(C=C3)F)=O)C4=C1C=CC=C4)O.[Rotation (+)]
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Prostaglandin Receptor
Isoform
– DP
Pathway
– GPCR/G Protein
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
