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Products Details
Product Description
– c-Met-IN-11 (compound 3) is a potent c-MET and VEGFR-2 inhibitor, with IC50 values of 41.4 and 71.1 nM, respectively[1].
Web ID
– HY-147694
Shipping
– Room temperature
Applications
– Cancer-Kinase/protease
Molecular Formula
– C30H20F2N4O3
References
– [1]Xu H, et al. Discovery of N-substituted-3-phenyl-1,6-naphthyridinone derivatives bearing quinoline moiety as selective type II c-Met kinase inhibitors against VEGFR-2. Bioorg Med Chem. 2020 Jun 15;28(12):115555.
CAS Number
– 1446324-05-5
Molecular Weight
– 522.50
SMILES
– COC1=CC2=NC=CC(OC3=C(C=C(C=C3)NC4=C5C(C(C6=CC=C(C=C6)F)=CNC5=CC=N4)=O)F)=C2C=C1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– c-Met/HGFR;VEGFR
Isoform
– VEGFR2/KDR/Flk-1
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
