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Products Details
Product Description
– BM-1074 is a potent and specific Bcl-2/Bcl-xL inhibitor with Ki values of < 1 nM and IC50 values of 1.8 nM and 6.9 nM for Bcl-2 and Bcl-xL, respectively. BM-1074 induces apoptosis, and exhibits antiproliferative activity against four small-cell lung cancer cell lines (H146, H1963, H187 and H1417) with IC50 values of 1-2 nM[1].
Web ID
– HY-13846
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C50H57ClN8O7S3
References
– [1]Angelo Aguilar, et al. A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. J Med Chem. 2013 Apr 11;56(7):3048-3067.
CAS Number
– 1391108-10-3
Molecular Weight
– 1013.69
SMILES
– O=C(C1=C(C)N(C(C)C)C(C2=CC=C(Cl)C=C2)=C1C3=CC=CC(N4CCN(C5=CC=C(NS(=O)(C6=CC=C(N[C@H](CCN(C)C)CSC7=CC=CC=C7)C([N+]([O-])=O)=C6)=O)C=C5)CC4)=C3)NS(=O)(C)=O
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family
Isoform
– Bcl-2;Bcl-xL
Pathway
– Apoptosis
Product type
– Reference compound
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