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Products Details
Product Description
– Bcl-2-IN-9 is a novel proapoptotic Bcl-2 inhibitor with IC50 value of 2.9 μM and low cytotoxic. Bcl-2-IN-9 mediates apoptosis by down-regulating expression of Bcl-2 in cancer cells and has a high selectivity against leukemia cells[1].
Web ID
– HY-149009
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C27H31N7O3S
References
– [1]Yukari Ono, et al. Design and synthesis of quinoxaline-1,3,4-oxadiazole hybrid derivatives as potent inhibitors of the anti-apoptotic Bcl-2 protein. Bioorg Chem. 2020 Aug; 104: 104245.
CAS Number
– 2490542-33-9
Molecular Weight
– 533.65
SMILES
– CN1CCN(C2=NC3=CC=CC=C3N=C2SC4=NN=C(C5=CC=C(OCCN6CCOCC6)C=C5)O4)CC1
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis;Bcl-2 Family
Isoform
– Bcl-2
Pathway
– Apoptosis
Product type
– Reference compound
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