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Products Details
Product Description
– APG-2449 is an orally active ALK/ROS1/FAK inhibitor. APG-2449 shows antitumor activity in mouse models of non-small cell lung cancer (NSCLC)[1].
Web ID
– HY-155163
Shipping
– Room temperature
Molecular Formula
– C33H42ClN5O4S
References
– [1]Fang DD, et al. Discovery of a novel ALK/ROS1/FAK inhibitor, APG-2449, in preclinical non-small cell lung cancer and ovarian cancer models. BMC Cancer. 2022 Jul 11;22(1):752.
CAS Number
– 2196186-84-0
Molecular Weight
– 640.24
SMILES
– O=S(C1=C(NC2=NC(NC3=CC(C)=C(C4=CCN(C5CCOCC5)CC4)C=C3OC(C)C)=NC=C2Cl)C=CC=C1)(C(C)C)=O
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Anaplastic lymphoma kinase (ALK);FAK;ROS Kinase
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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