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Products Details
Product Description
– AP 24149 is a potent Src-Abl dual inhibitor with IC50 values of 9.1, 3.6 nM for Src and Abl, respectively[1].
Web ID
– HY-10363
Shipping
– Room temperature
Molecular Formula
– C23H24N5OP
References
– [1]Zhou T, et al. Structural analysis of DFG-in and DFG-out dual Src-Abl inhibitors sharing a common vinyl purine template. Chem Biol Drug Des. 2010 Jan;75(1):18-28.
CAS Number
– 926922-29-4
Molecular Weight
– 417.44
SMILES
– O=P(C)(C)C(C=C1)=CC=C1NC2=C3N=CN(/C=C/C4=C(C)C=CC=C4C)C3=NC=N2
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Bcr-Abl;Src
Isoform
– Abl
Pathway
– Protein Tyrosine Kinase/RTK
Product type
– Reference compound
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