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Products Details
Product Description
– Anti-osteoporosis agent-4 (Compound 11h) inhibits differentiation of primary osteoclasts. Anti-osteoporosis agent-4 attenuates RANKL-induced osteoclastogenesis. Anti-osteoporosis agent-4 inhibits osteoclast formation with an IC50 value of 358.29 nM. Anti-osteoporosis agent-4 inhibits PI3K/AKT and IκBα/NF-κB signaling pathway activation[1].
Web ID
– HY-149472
Shipping
– Room temperature
Molecular Formula
– C26H26ClN3O7S
References
– [1]Chen Z, et al. Synthesis and evaluation of 2-NMPA derivatives as potential agents for prevention of osteoporosis in vitro and in vivo. Eur J Med Chem. 2023 Aug 28;260:115767.
Molecular Weight
– 560.02
SMILES
– O=S(C1=CC=C(NC(C)=O)C=C1)(OC2=CC=C(NC(COC3=CC=CC=C3Cl)=O)C(N4CCOCC4)=C2)=O
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– NF-κB;PI3K
Pathway
– NF-κB;PI3K/Akt/mTOR
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
