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Products Details
Product Description
– Anti-inflammatory agent 55 (compound 9j) is a derivative of Coixol and has anti-inflammatory activity. Anti-inflammatory agent 54 inhibits the NF-κB pathway and downregulates the expression of iNOS, TNF-α, IL-6 and IL-1β. Anti-inflammatory agent 54 inhibits LPS-induced nitric oxide (NO) production in RAW264.7 macrophages (IC50: 0.8 μM) and exerts in vivo anti-inflammatory activity in a mouse auricular edema model[1].
Web ID
– HY-155821
Shipping
– Room temperature
Molecular Formula
– C17H15N3O7
References
– [1]Cui E, et al. Discovery of Coixol Derivatives as Potent Anti-inflammatory Agents. J Nat Prod. 2023 Aug 25;86(8):1950-1959..
CAS Number
– 2924156-51-2
Molecular Weight
– 373.32
SMILES
– O=C(NCCN1C(OC2=CC(OC)=CC=C12)=O)/C=C/C3=CC=C([N+]([O-])=O)O3
Clinical Information
– No Development Reported
Research Area
– Inflammation/Immunology
Solubility
– 10 mM in DMSO
Target
– Interleukin Related;NF-κB;NO Synthase;TNF Receptor
Pathway
– Apoptosis;Immunology/Inflammation;NF-κB
Product type
– Reference compound
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
