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Products Details
Product Description
– Afabicin (Debio 1450) is the proagent of Debio1452, specifically targeting staphylococci without significant activity against other Gram-positive or Gram-negative species. Debio1452 is an inhibitor FabI, an enzyme critical to fatty acid biosynthesis in staphylococci[1].
Web ID
– HY-109000A
Shipping
– Room temperature
Applications
– COVID-19-immunoregulation
Molecular Formula
– C23H22N3Na2O7P
References
– [1]Flamm RK, et al. Activity of Debio1452, a FabI inhibitor with potent activity against Staphylococcus aureus and coagulase-negative Staphylococcus spp., including multidrug-resistant strains. Antimicrob Agents Chemother. 2015;59(5):2583-2587.
CAS Number
– 1518800-29-7
Molecular Weight
– 529.39
SMILES
– O=P(O[Na])(O[Na])OCN1C2=NC=C(/C=C/C(N(C)CC(OC3=CC=CC=C43)=C4C)=O)C=C2CCC1=O
Clinical Information
– Phase 2
Research Area
– Infection
Solubility
– 10 mM in DMSO
Target
– Bacterial
Pathway
– Anti-infection
Product type
– Reference compound
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