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Product Description
– ADPM06, a lead candidate azadipyrromethene, is a novel nonporphyrin photodynamic therapeutic (PDT) agent. ADPM06 exhibits IC50 values in the micro-molar range in human tumor cells and induces apoptosis[1].
Web ID
– HY-13547
Shipping
– Room temperature
Applications
– Cancer-programmed cell death
Molecular Formula
– C34H24BBr2F2N3O2
References
– [1]W M Gallagher, et al. A potent nonporphyrin class of photodynamic therapeutic agent: cellular localisation, cytotoxic potential and influence of hypoxia. Br J Cancer. 2005 May 9; 92(9): 1702-1710.|[2]Aisling E O’Connor, et al. Mechanism of cell death mediated by a BF2-chelated tetraaryl-azadipyrromethene photodynamic therapeutic: dissection of the apoptotic pathway in vitro and in vivo. Int J Cancer. 2012 Feb 1;130(3):705-15.
CAS Number
– 490035-90-0
Molecular Weight
– 715.19
SMILES
– [F-][B+3]1([N]2=C(C3=CC=C(OC)C=C3)C(Br)=C(C4=CC=CC=C4)C2=NC5=C(C(Br)=C([N-]51)C6=CC=C(OC)C=C6)C7=CC=CC=C7)[F-]
Clinical Information
– No Development Reported
Research Area
– Cancer
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Reference compound
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