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Product Description
– 2,3-Dihydro-3α-methoxynimbolide is a limonoid compound isolated from the extracts of bark, leaves, roots, and seeds of Azadirachta indica A. Juss. var. siamensis Valeton. 2,3-Dihydro-3α-methoxynimbolide exhibits potent cyto-toxicities against one or more cell lines. 2,3-Dihydro-3α-methoxynimbolide activates caspases-3, -8, and -9, while increases the ratio of Bax/Bcl-2. 2,3-Dihydro-3α-methoxynimbolide induces apoptosis via both mitochondrial and death receptor pathways in AZ521[1].
Web ID
– HY-N10091
Shipping
– Room temperature
Molecular Formula
– C28H34O8
References
– [1] Manosroi A, et al. Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities. Chem Biodivers. 2014;11(4):505-531.
CAS Number
– 1607828-35-2
Molecular Weight
– 498.56
SMILES
– C[C@@]12[C@@](O[C@@]3([H])C2=C([C@@](C4=COC=C4)([H])C3)C)([H])[C@@]5([H])[C@]6([H])[C@@]([C@H]1CC(OC)=O)(C(C[C@H]([C@]6(C(O5)=O)C)OC)=O)C
Clinical Information
– No Development Reported
Research Area
– Others
Solubility
– 10 mM in DMSO
Target
– Apoptosis
Pathway
– Apoptosis
Product type
– Natural Products
Disclaimer: All products are for Research use only unless clearly stated otherwise on the product datasheet. Datasheets provided on the website are drafts for reference purpose only and you are requested to always refer to the hard copy included in the kit for your experimentation. Agdia Products are available for delivery only in Canada.
